O ZOOTYL 945,000 IU/g powder for administration in drinking water for pigs, chickens, chickens and turkeys is indicated for the treatment and metaphylaxis of chronic respiratory disease (CRD). Treatment of necrotic enteritis caused by Clostridium perfringens in broilers and laying hens; in the treatment and metaphylaxis of infectious sinusitis in turkeys; and in the treatment of porcine proliferative enteritis or ileitis caused by Lawsonia intracellularis in pigs. The presence of the disease in the farm/flock must be established before metaphylactic treatment.